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New Treatment for Ileitis & Colitis

mjm Junior Member
edited June 2012 in Vets and Producers
Ileitis is an inflammation of the small intestine. It is also known as Porcine Enteropathy and a cause of significant health and performance problem in many swine herds. Affected growing hogs can show wasting, diarrhoea and increased mortality. On autopsy examination there is tyically proliferation and thickening of the lower small intestine.

Colitis is an inflammation of the large intestine and is another common disease of grower pigs, which typically show a sloppy "cow pat" type scour. A 2% premix (tiamulin hydrogen fumarate) called Denagard has been approved for in-feed treatment of both ileitis and colitis, adding to its original usage as a treatment and prevention for swine dysentery and as an aid in the control of enzootic pneumonia of swine.

Tiamulin was first described as an effective treatment of ileitis as long ago as 1981 by a Yorkshire vet, David Jennings. After medicating their drinking water, mortality decreased and the incidence of emaciated pigs disappeared. However water medication is not always practical and is expensive.

It was not until the 1990's that Gordon Lawson of Edinburgh University Veterinary School, was able to grow the causative bacteria of ileitis, Lawsonia intracellularis. This led to Steve McOrist, now of Nottingham University, testing the activity of a number of antimicrobial drugs that might be used to treat the disease
He infected pigs orally with infected cell-cultures then placed them on tiamulin medication either 2 days before infection (prevention) or seven days after infection (treatment) - the trial was terminated 21 days after infection. Tiamulin given in feed was highly effective for both the treatment and prevention of ileitis.

In 2007 10 U.S. and EU isolates of L. intracellularis, were tested to determine the intracellular minimum inhibitory concentration (MIC) of tiamulin, which was 0.125µg/ml - adequate for a strong therapeutic effect. Tiamulin achieves high levels in the colon contents as well as in the ileum - concentrations adequate for medication of the colitis bacteria B. pilosicoli and B. hyodysenteriae.
For a free report from Octagon Services on the new treatment - illustrated with graphs, tables and a reference list - go to: www.pighealth.com

Comments

  • mjm Junior Member
    edited April 2012
    New EU research has explored the technical basis for using Tiamulin to treat Ileitis and "Porcine Proliferative Enteropathy" (PPE) in swine. An illustrated report is available online:
    www.octagon-services.co.uk/articles/ileitisPKPD.pdf
  • blonde Senior Member
    edited May 2012
    mjm said:
    New EU research has explored the technical basis for using Tiamulin to treat Ileitis and "Porcine Proliferative Enteropathy" (PPE) in swine. An illustrated report is available online:
    www.octagon-services.co.uk/articles/ileitisPKPD.pdf
    we used an injectable antibiotic for ileitis
  • Stevie G Super Moderator
    edited May 2012
    blonde said:
    we used an injectable antibiotic for ileitis
    `

    Why not just vaccinate against it with Enterisol Ileitis, farther than use drugs????
    I would be alot cheaper and make more sense???:cool:
  • blonde Senior Member
    edited May 2012
    Stevie G said:
    `

    Why not just vaccinate against it with Enterisol Ileitis, farther than use drugs????
    I would be a lot cheaper and make more sense???:cool:
    we only had to do it once when pigs were sick and we have had no more trouble. It was only in 2 pens of growers
  • mjm Junior Member
    edited June 2012
    Thanks for your input on this important disease problem, guys.
    This paper on in-feed treatments for Ileitis was presented at the recent International Pig Veterinary Society Congress and is now available online:
    http://www.octagon-services.co.uk/articles/ileitis2012.pdf
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